The main interests of my group focus on innate-like immune responses, including unconventional memory CD8 T lymphocyte responses during gammaherpesvirus and helminth/virus coinfections. We investigate host-pathogen interactions based on two specific infectious disease models in animal and human. First, we are investigating the pathogenesis of wildebeest-derived malignant catarrhal fever induced by the lymphotropic γ-herpesvirus alcelaphine herpesvirus 1 (AlHV-1), in particular we seek to determine how this virus induces a fatal peripheral T cell lymphoma in non-natural hosts such as cattle. Second, we are investigating immune-related protective mechanisms using mouse models of helminth parasite infections and how the resulting type 2-skewed immunity interferes with co-infection with other pathogens, such as viruses.
Equipment / technologies
In vivo imaging system (IVIS)
Molecular biology – BAC cloning
Multicolour flow cytometry and cell sorting
Prize of the 'Centre d'Etudes Princesse Jospéhine-Charlotte' 2019
Award of the Veterinary Medicine Annals 2002
Comte de Launois Award (Friends of ULg) 2014
BAEF Alumni Award 2014
Most representative publications
Myster F, Gong MJ, Javaux J, Suárez NM, Wilkie GS, Connelley T, Vanderplasschen A, Davison AJ, DEWALS BG. Alcelaphine Herpesvirus 1 Genes A7 and A8 Regulate Viral Spread and Are Essential for Malignant Catarrhal Fever. PLoS Pathog. 2020 Mar 16;16(3):e1008405. http://hdl.handle.net/2268/247039
Darby MG, Chetty A, Mrjden D, Rolot M, Smith K, Mackowiak C, Sedda D, Nyangahu D, Jaspan H, Toellner KM, Waisman A, Quesniaux V, Ryffel B, Cunningham AF, DEWALS BG, Brombacher F, Horsnell WGC. Pre-conception Maternal Helminth Infection Transfers via Nursing Long-Lasting Cellular Immunity Against Helminths to Offspring. Sci Adv. 2019 May 29;5(5):eaav3058. http://hdl.handle.net/2268/237111
Rolot M, M Dougall A, Javaux J, Lallemand F, Machiels B, Martinive P, Gillet L, DEWALS BG. Recruitment of hepatic macrophages from monocytes is independent of IL-4Rα but is associated with ablation of resident macrophages in schistosomiasis. Eur J Immunol. 2019 Jul;49(7):1067-1081.
Rolot M, Dougall AM, Chetty A, Javaux J, Chen T, Xiao X, Machiels B, Selkirk ME, Maizels RM, Hokke C, Denis O, Brombacher F, Vanderplasschen A, Gillet L, Horsnell WGC, DEWALS BG. Helminth-induced IL-4 Expands Bystander Memory CD8 + T Cells for Early Control of Viral Infection. Nat Commun. 2018 Oct 30;9(1):4516.
Sorel O, Chen T, Myster F, Javaux J, Vanderplasschen A, DEWALS BG. Macavirus latency-associated protein evades immune detection through regulation of protein synthesis in cis depending upon its glycin/glutamate-rich domain. PLoS Pathog. 2017 Oct 23;13(10):e1006691. http://hdl.handle.net/2268/216816
Palmeira, L., Sorel O., Van Campe W., Boudry C., Roels S., Myster F., Reschner A., Coulie P.G., Kerkhofs P., Vanderplasschen A. et DEWALS BG. An essential role for gamma-herpesvirus latency-associated nuclear antigen homolog in an acute lymphoproliferative disease of cattle. Proc Natl Acad Sci U S A. 2013, 110, 21:E1933-42 http://hdl.handle.net/2268/148679
Information updated by the researcher on 30/04/2020.
Previous lab members
Steven van Beurden
PhD student had honour the 18/03/17