Vanderplasschen Alain

Researcher, Ordinary Professor
Researcher publications

 

Research subjects

Alain Vanderplasschen scientific carrier is characterized by the development of both fundamental and applied researches. His group contributed to unravel key fundamental host-pathogen interactions occurring between pathogens (mainly but not exclusively herpesviruses) and their hosts. These interactions are related to pathogen entry into the host, pathogenesis, immune evasion mechanisms developed by viruses (soluble cytokine receptors, virokines, evasion of complement). The Immunology-Vaccinology laboratory has a strong expertise in bacterial artifical cloning of herpesviruses genomes and production of recombinant viruses using prokaryotic recombination technologies. Using this expertise, the lab has produced a long list of recombinant viruses for fundamental and applied researches. Recombinant herpesviruses encoding luciferase expression cassette and in vivo bioluminescent imaging system (IVIS) were used to study viral tropism and the potential of recombinant viruses as vaccine vectors. Recombinants deleted for specific genes were also produced as live attenuated candidate vaccines with predicted biological properties. The Immunology-Vaccinology laboratory developed original techniques to produce antibodies using DNA vaccination in rabbit and mice. This approach is now being extended to alpagas.

Equipment / technologies

Flow cytometry

In vivo biolumiscent Imaging System

Molecular and cellular biology

Academic distinctions

Laureat of scientific prizes among which 

« prix de l’industrie du médicament vétérinaire » (1996-1997)

« prix Hamoir » (1993-1997)

« prix Edouard Van Beneden » (1995-2000)

« Prix Jaumain » (2003)

« Prix centre d’étude Joséphine-Charlotte » (2009)

Author of 6 patents

Most representative publications

  • Boutier M., Ronsmans M., Ouyang P., Fournier G., Reschner A., Rakus K., Wilkie G., Farnir F., Bayrou C., Lieffrig F., Li H., Desmecht D., Davison A. et  VANDERPLASSCHEN A. Rational Development of an Attenuated Recombinant Cyprinid Herpesvirus 3 Vaccine Using Prokaryotic Mutagenesis and In Vivo Bioluminescent Imaging. PLOS Pathogens. 10.1371/journal.ppat.1004690. 2015, 11, 2, e1004690 http://orbi.ulg.ac.be/handle/2268/179932
  • Palmeira L., Sorel O., Van Campe W., Boudry Ch., Roels S., Myster F., Reschner A., Coulie P., Kerkhofs P., VANDERPLASSCHEN A., Dewals B. An essential role for gamma-herpesvirus latency-associated nuclear antigen homolog in an acute lymphoproliferative disease of cattle. PNAS. 2013 http://hdl.handle.net/2268/148679
  • Machiels B., Stevenson P.G., VANDERPLASSCHEN A et Gillet L. A gammaherpesvirus uses alternative splicing to regulate its tropism and its sensitivity to neutralization. PLOS Pathogens. 2013 http://orbi.ulg.ac.be/handle/2268/158959
  • VANDERPLASSCHEN A.  Brevet. 2011 http://worldwide.espacenet.com/publicationDetails/biblio?CC=WO&NR=2013098214A1&KC=A1&FT=D&ND=4&date=20130704&DB=EPODOC&locale=en_EP
  • Costes B., Stalin Raj V., Michel B., Fournier G., Thirion M., Gillet L., Mast J., Lieffrig F., Brémont M. et  VANDERPLASSCHEN A. The major portal of entry of koi herpesvirus in cyprinus carpio is the skin. Journal of Virology. 2009 http://hdl.handle.net/2268/28938
  • Gillet L., Dewals B., Farnir F.,  et de Leval L. et VANDERPLASSCHEN A. Bovine herpesvirus 4 induces apoptosis of human carcinoma cell lines in vitro and in vivo. Cancer Research. 2005, 65, 20, 9463-9472 http://orbi.ulg.ac.be/handle/2268/29143 
  • VANDERPLASSCHEN A., et al. A Multipotential Beta -1,6-N-Acetylglucosaminyl-Transferase Is Encoded by Bovine Herpesvirus Type 4. PNAS. 2000, 97, 11, 5756-5761  http://orbi.ulg.ac.be/handle/2268/8114 

Information updated by the researcher on 15/10/2015.

PhD students

Ronsmans Maygane

Gandar Frédéric

Boutier Maxime

Vancsok Catherine

Morvan Léa

Gao Yuan

Postdocs or other

Rakus Krzysztof

Jazowiecka Joanna

Penaranda Ma. Michelle

Harmegnies Natacha